Mexanim-PLUS

Description

MEXANIM-PLUS combines Nimesulide, Paracetamol, Phenylephrine Hydrochloride and Caffeine in tablet form. The formulation is designed to provide combined symptomatic support for pain and selected cold-related symptoms. Nimesulide and paracetamol provide pain-relieving action, while phenylephrine helps relieve nasal congestion and caffeine can complement the analgesic effect of some pain-relief formulations.

For related pain-management, cold-care and pharmaceutical formulations, visit the Medhexa Pharma Products range.

Therapeutic Segment

Pain Management | Analgesics | NSAIDs | Cold & Flu Care | Nasal Decongestants

Uses of MEXANIM-PLUS

MEXANIM-PLUS may be prescribed for short-term symptomatic relief when pain occurs together with cold-related symptoms such as nasal congestion.

Depending on the patient’s symptoms and healthcare professional’s assessment, the combination may support:

• Headache and body aches associated with cold symptoms
• Fever and general pain
• Nasal congestion
• Discomfort associated with common cold symptoms
• Short-term pain and inflammatory symptoms when nimesulide is considered appropriate

The exact indication should follow the approved product information and prescribing advice applicable to the specific formulation and market.

Key Benefits of MEXANIM-PLUS

• Pain Relief: Nimesulide and paracetamol provide analgesic action through different mechanisms.
• Fever Support: Paracetamol helps reduce fever and relieve common aches and pains.
• Nasal Decongestant Support: Phenylephrine helps reduce swelling of the nasal blood vessels, which can ease nasal congestion.
• Analgesic Support: Caffeine is included in some analgesic combinations and may enhance the pain-relieving effect.
• Combination Formulation: Brings multiple symptomatic ingredients together in one tablet.
• Convenient Oral Form: Supplied as tablets for convenient administration.

How MEXANIM-PLUS Works

Each ingredient contributes a different action to the formulation.

Nimesulide belongs to the NSAID class and reduces the production of prostaglandins involved in pain and inflammation. Because systemic nimesulide has important liver-safety restrictions, healthcare professionals recommend its use only when appropriate and for the shortest suitable duration.

Paracetamol provides analgesic and antipyretic effects. It helps reduce pain and fever associated with several common conditions.

Phenylephrine Hydrochloride acts as a nasal decongestant. It causes vasoconstriction in the nasal mucosa, which can reduce nasal swelling and help improve a blocked nose.

Caffeine acts as a central nervous system stimulant and is included in some analgesic combinations to complement pain-relief effects.

Common Side Effects of MEXANIM-PLUS

Some people may experience side effects related to one or more ingredients. Possible effects include:

• Nausea
• Stomach discomfort or indigestion
• Headache
• Dizziness
• Increased heart rate or palpitations
• Difficulty sleeping
• Nervousness or restlessness
• Dry mouth

Nimesulide can cause gastrointestinal adverse effects and has important liver-related safety concerns. Phenylephrine may also cause cardiovascular effects in susceptible individuals.

Seek medical attention if you experience severe abdominal pain, persistent vomiting, unusual tiredness, dark urine, yellowing of the skin or eyes, chest pain, severe palpitations or difficulty breathing.

Important Safety Information

• Use MEXANIM-PLUS only as directed by a qualified healthcare professional.
• Do not combine it with other medicines containing paracetamol unless your healthcare professional specifically advises it.
• Avoid taking MEXANIM-PLUS with other NSAIDs unless specifically recommended.
• Systemic nimesulide carries important liver-safety restrictions. EMA guidance limits treatment to short-term use and recommends a maximum duration of 15 days in its regulatory framework.
• Do not use nimesulide for prolonged self-treatment of pain.
• Inform your doctor if you have liver disease, kidney disease, stomach ulcers, gastrointestinal bleeding, heart disease or high blood pressure.
• Phenylephrine may require caution in people with hypertension, cardiovascular disease, hyperthyroidism, glaucoma or certain urinary conditions.
• Caffeine may cause nervousness, restlessness, palpitations or sleep difficulties, particularly in caffeine-sensitive individuals.
• Avoid excessive alcohol consumption during treatment because it can increase the risk of adverse effects, particularly those involving the liver and gastrointestinal tract.
• Tell your doctor about all medicines and supplements you take, especially other painkillers, cold medicines, decongestants, anticoagulants and medicines that may affect the liver or blood pressure.
• Pregnant or breastfeeding women should use the product only after appropriate medical advice.
• Keep the medicine out of reach of children.

For detailed information on systemic nimesulide safety restrictions, refer to the European Medicines Agency nimesulide review.

Dosage & Administration

Take MEXANIM-PLUS exactly as prescribed by your healthcare professional.

The appropriate dose depends on the patient’s symptoms, medical history and the approved formulation. Since the individual ingredient strengths were not provided, a specific dosing schedule should not be stated here.

Do not exceed the recommended dose. In particular, check other cold, flu or pain medicines carefully to avoid taking additional paracetamol, NSAIDs, phenylephrine or caffeine.

Do not continue treatment for longer than recommended, particularly because the formulation contains systemic nimesulide.

Storage

• Store in a cool, dry place.
• Protect from direct sunlight and excessive moisture.
• Keep the tablets inside the original blister until use.
• Keep out of reach of children.
• Do not use after the expiry date.