Description
RABIMEXA-ASR combines Rabeprazole 20 mg with Aceclofenac 200 mg in a sustained-release formulation. Rabeprazole reduces gastric acid secretion, while Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation. This combination brings acid suppression together with analgesic and anti-inflammatory therapy and may be prescribed for painful inflammatory conditions where a healthcare professional considers both components appropriate. CDSCO has documented the 200 mg Aceclofenac SR and 20 mg Rabeprazole combination for painful inflammatory conditions associated with gastroduodenal ulcers.
For related pain-management, gastrointestinal and other pharmaceutical formulations, explore the Medhexa Pharma product range.
Therapeutic Segment
Pain Management | Anti-Inflammatory Therapy | NSAIDs | Gastrointestinal Care | Acid Suppression
Uses of RABIMEXA-ASR
RABIMEXA-ASR may be prescribed when both pain and inflammation require treatment and gastric acid suppression is also considered appropriate.
Potential clinical uses include:
- Painful inflammatory conditions
- Musculoskeletal pain associated with inflammation
- Joint and inflammatory pain
- Osteoarthritis-related pain and inflammation
- Rheumatoid arthritis-related pain and inflammation
- Other painful inflammatory conditions where Aceclofenac is appropriate
The combination has also been documented by CDSCO for painful inflammatory conditions associated with gastroduodenal ulcers.
The exact indication should always depend on the patient’s diagnosis and the healthcare professional’s assessment.
Key Benefits of RABIMEXA-ASR
RABIMEXA-ASR combines two medicines with different therapeutic actions:
- Aceclofenac 200 mg SR helps reduce pain and inflammation.
- Rabeprazole 20 mg suppresses gastric acid production.
- The sustained-release Aceclofenac formulation provides modified drug release.
- The combination brings anti-inflammatory therapy and acid suppression into one capsule.
- The capsule dosage form allows convenient oral administration.
- Supplied in 10 × 10 ALU-ALU packaging.
Aceclofenac 200 mg sustained-release formulations are used for pain and inflammatory conditions such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
How RABIMEXA-ASR Works
Aceclofenac belongs to the NSAID class. It reduces the formation of prostaglandins by inhibiting cyclooxygenase-related pathways. Since prostaglandins contribute to pain and inflammation, reducing their production helps manage inflammatory pain.
Rabeprazole belongs to the proton pump inhibitor (PPI) class. It inhibits the H⁺/K⁺-ATPase proton pump in gastric parietal cells, thereby reducing gastric acid secretion.
Therefore, RABIMEXA-ASR combines anti-inflammatory and analgesic action with gastric acid suppression.
Common Side Effects of RABIMEXA-ASR
Some patients may experience side effects from Aceclofenac or Rabeprazole.
Possible effects include:
- Indigestion
- Nausea
- Abdominal discomfort
- Diarrhea
- Constipation
- Vomiting
- Headache
- Dizziness
- Flatulence
- Stomach irritation
NSAIDs such as Aceclofenac can also cause gastrointestinal ulceration or bleeding, particularly with prolonged use or in patients with risk factors.
If symptoms become severe, persistent or unusual, seek medical advice promptly.
Important Safety Information
RABIMEXA-ASR should be used only under the guidance of a qualified healthcare professional.
Aceclofenac is an NSAID and can increase the risk of gastrointestinal bleeding, ulceration and perforation. The risk can increase with longer treatment duration, higher exposure and certain patient factors.
Inform your healthcare professional before using this medicine if you have:
- A history of stomach ulcer or gastrointestinal bleeding
- Severe kidney disease
- Liver disease
- Heart failure or significant cardiovascular disease
- Uncontrolled hypertension
- Asthma or previous reactions to aspirin or other NSAIDs
- Blood-clotting or bleeding disorders
NSAIDs can also cause fluid retention, increased blood pressure and deterioration of kidney function in susceptible patients. Therefore, patients with cardiovascular, renal or hepatic risk factors may require monitoring.
Do not combine RABIMEXA-ASR with another NSAID unless specifically advised by a healthcare professional. Also inform your doctor about medicines such as anticoagulants, antiplatelet medicines, corticosteroids, diuretics, antihypertensives and other medicines that may interact with NSAIDs.
Rabeprazole can interact with certain medicines. For example, PPIs including Rabeprazole are contraindicated with rilpivirine-containing products, and additional monitoring may be required with medicines such as warfarin.
Long-term PPI therapy can also be associated with conditions such as vitamin B12 deficiency, low magnesium levels and certain bone-related risks. Prolonged treatment should therefore remain under appropriate medical supervision.
Pregnant patients should seek medical advice before using RABIMEXA-ASR. NSAID use, particularly later in pregnancy, requires specific medical consideration.
For current safety information regarding Aceclofenac, consult the Indian Pharmacopoeia Commission and the applicable product prescribing information.
Dosage & Administration
Take RABIMEXA-ASR exactly as prescribed by your healthcare professional.
The appropriate dose and duration depend on the patient’s condition, severity of symptoms, other medicines and individual risk factors.
Swallow the capsule whole with water. Do not crush, chew or break the sustained-release formulation, as doing so may alter the intended release of Aceclofenac.
Aceclofenac 200 mg sustained-release formulations are commonly designed for modified-release administration; however, the exact regimen for RABIMEXA-ASR should follow the approved product information and prescription.
Use the lowest effective NSAID exposure for the shortest appropriate duration as directed by the healthcare professional, particularly in patients with gastrointestinal, cardiovascular or renal risk factors.
Do not take additional painkillers containing Aceclofenac or another NSAID unless your healthcare professional advises you to do so.
Storage
Store RABIMEXA-ASR in a cool, dry place away from excessive heat, moisture and direct sunlight.
Keep the capsules in their original ALU-ALU packaging until use.
Follow the specific storage instructions printed on the product packaging.
Keep out of reach of children.
