Description
ESOHEX-DSR combines Esomeprazole 40 mg with Domperidone 30 mg in a sustained-release formulation. Esomeprazole reduces gastric acid production, while Domperidone supports gastrointestinal motility and helps manage nausea and vomiting in appropriate clinical situations. Therefore, healthcare professionals may prescribe this combination for selected adults with gastroesophageal reflux disease (GERD), particularly when Esomeprazole alone does not provide adequate control.
For related gastrointestinal formulations and other pharmaceutical products, explore the Medhexa Pharma product range.
Therapeutic Segment
Gastrointestinal Care | Acid-Related Disorders | GERD Management | Proton Pump Inhibitors | Prokinetic Therapy
Uses of ESOHEX-DSR
ESOHEX-DSR may support the management of gastroesophageal reflux disease (GERD) and related acid-reflux symptoms. Esomeprazole reduces gastric acid secretion, which can help relieve heartburn and other acid-related symptoms. It can also support healing in certain acid-related esophageal conditions.
In addition, Domperidone helps manage nausea and vomiting in approved situations by supporting gastrointestinal movement. However, healthcare professionals should select Domperidone only for appropriate indications because the medicine has important safety considerations.
Potential clinical uses include:
- Gastroesophageal reflux disease (GERD)
- Acid reflux and associated heartburn
- Acid-related upper gastrointestinal symptoms
- GERD accompanied by nausea or vomiting when clinically appropriate
- Selected adult GERD cases where Esomeprazole alone does not provide adequate response
The prescribing healthcare professional should determine the exact indication according to the patient’s condition and approved product information.
Key Benefits of ESOHEX-DSR
ESOHEX-DSR combines two medicines that provide complementary gastrointestinal actions.
- Esomeprazole 40 mg reduces gastric acid secretion.
- Domperidone 30 mg SR supports gastrointestinal motility and helps manage nausea and vomiting in appropriate indications.
- The combination addresses acid-related symptoms alongside selected gastrointestinal symptoms.
- The sustained-release formulation provides modified release of Domperidone.
- The capsule dosage form offers convenient administration.
- The product comes in 10 × 10 ALU-ALU packaging.
Moreover, Esomeprazole directly targets the final stage of gastric acid production by inhibiting the gastric proton pump.
How ESOHEX-DSR Works
First, Esomeprazole acts as a proton pump inhibitor. It inhibits the H⁺/K⁺-ATPase enzyme system in the gastric parietal cells. As a result, the stomach produces less acid. This action helps control acid-related symptoms and supports the healing of acid-related damage in appropriate conditions.
Meanwhile, Domperidone mainly blocks dopamine receptors and promotes gastrointestinal motility. It also helps control nausea and vomiting in approved indications.
Thus, ESOHEX-DSR combines gastric acid suppression with gastrointestinal motility and antiemetic support.
Common Side Effects of ESOHEX-DSR
Some patients may experience side effects while taking medicines containing Esomeprazole or Domperidone. Common effects can include:
- Headache
- Nausea
- Diarrhea
- Abdominal pain or discomfort
- Constipation
- Flatulence
- Dry mouth
- Dizziness
However, side effects can vary from person to person. If symptoms become severe, persistent or unusual, consult a healthcare professional.
In particular, seek prompt medical attention if you experience fainting, palpitations, an irregular heartbeat or other symptoms that may indicate a heart rhythm problem. Domperidone can increase the risk of serious ventricular arrhythmias in susceptible patients.
Important Safety Information
Use ESOHEX-DSR only under the direction of a qualified healthcare professional.
Because Domperidone can affect cardiac electrical activity, discuss your medical history and current medicines with your healthcare professional before starting treatment. Domperidone can increase the risk of QT-interval prolongation and serious ventricular arrhythmias. The risk becomes more important in patients with certain heart conditions, electrolyte abnormalities or relevant drug interactions.
Furthermore, patients above 60 years of age and patients taking higher daily Domperidone doses may face greater cardiac risk. Medicines that prolong the QT interval or strongly inhibit CYP3A4 can also increase this risk.
Patients with known QT prolongation, significant electrolyte disturbances, bradycardia, certain cardiac diseases or severe hepatic impairment may need to avoid Domperidone.
Since ESOHEX-DSR contains Domperidone 30 mg SR, follow the prescribed schedule carefully. Do not increase the dose or frequency on your own.
Esomeprazole also requires appropriate medical supervision in patients with liver problems or those who require prolonged PPI treatment. Long-term PPI therapy can affect certain nutrients and may increase some risks associated with prolonged acid suppression.
Therefore, tell your healthcare professional about all medicines, supplements and medical conditions before starting treatment. This information helps identify potential interactions and reduce avoidable risks.
Dosage & Administration
Take ESOHEX-DSR exactly as prescribed by your healthcare professional. The appropriate dosage and treatment duration depend on the patient’s condition, response to treatment and approved product information.
Esomeprazole delayed-release formulations generally require administration before meals. Swallow the capsule as directed and do not crush or chew the dosage form unless the specific product information provides another method.
Because ESOHEX-DSR contains Domperidone 30 mg SR, do not take additional Domperidone-containing medicines unless your healthcare professional specifically recommends them.
Moreover, do not increase, reduce or extend the treatment period without medical advice.
Storage
Store ESOHEX-DSR in a cool, dry place away from excessive heat, moisture and direct sunlight.
Keep the capsules in their original packaging until use. Also, keep the medicine out of reach of children.
Always follow the storage instructions printed on the product packaging.
