Description
METRACIN-PLUS combines Itraconazole, Ofloxacin, Ornidazole and Clobetasol Propionate in a topical cream formulation. This combination brings together antifungal, antibacterial, antimicrobial and anti-inflammatory actions. It may be prescribed for selected inflammatory skin conditions where fungal or bacterial involvement is clinically suspected and the healthcare professional considers all ingredients appropriate.
For related dermatology and skincare formulations, explore the Medhexa Pharma product range for pharmaceutical products and business enquiries.
Therapeutic Segment
Dermatology | Antifungal Therapy | Topical Antibacterial Therapy | Anti-inflammatory Therapy | Mixed Skin Infection Management
Uses of METRACIN-PLUS
METRACIN-PLUS may be prescribed for selected skin conditions involving infection together with significant inflammation, when treatment with its individual components is considered appropriate.
Depending on the diagnosis, it may support management of:
- Selected superficial fungal skin infections with inflammation
- Certain bacterial skin infections accompanied by inflammatory symptoms
- Mixed or complicated superficial skin infections
- Inflammatory skin conditions where an infectious component has been identified
- Localized skin irritation, redness and itching associated with appropriate infectious conditions
Because the cream contains Clobetasol Propionate, a high-potency topical corticosteroid, it should not be used routinely for undiagnosed rashes or simple fungal infections without medical advice. A healthcare professional should determine whether the combination is appropriate for the specific skin condition.
Key Benefits of METRACIN-PLUS
- Antifungal support: Itraconazole helps target susceptible fungal organisms.
- Antibacterial action: Ofloxacin provides antibacterial activity against susceptible bacteria.
- Antimicrobial activity: Ornidazole acts against susceptible anaerobic microorganisms and certain protozoal organisms.
- Inflammation control: Clobetasol Propionate helps reduce redness, swelling, itching and other inflammatory symptoms.
- Combination formulation: Brings multiple therapeutic actions together in one topical preparation.
- Localized application: Delivers the formulation directly to the affected skin area.
- Convenient cream format: Supplied in a 15 GM tube.
How METRACIN-PLUS Works
Each active ingredient contributes a different therapeutic action.
Itraconazole is an azole antifungal that interferes with the production of ergosterol, an essential component of fungal cell membranes. This action helps inhibit the growth of susceptible fungi.
Ofloxacin is a fluoroquinolone antibacterial agent. It inhibits bacterial enzymes involved in DNA replication and repair, thereby interfering with bacterial growth.
Ornidazole belongs to the nitroimidazole class. In susceptible microorganisms, it forms reactive compounds that damage microbial DNA and interfere with essential cellular processes.
Clobetasol Propionate is a potent topical corticosteroid. It reduces inflammatory activity in the skin and can help control redness, swelling and itching.
Together, these ingredients provide antifungal, antibacterial, antimicrobial and anti-inflammatory activity. However, using a combination product is appropriate only when the individual components match the diagnosed condition.
Common Side Effects of METRACIN-PLUS
Some individuals may experience local skin reactions after applying the cream. Possible effects include:
- Burning or stinging
- Itching
- Redness
- Skin irritation
- Dryness
- Peeling or scaling
- Local discomfort
Because METRACIN-PLUS contains Clobetasol Propionate, prolonged or inappropriate use can also increase the risk of:
- Skin thinning
- Stretch marks
- Visible small blood vessels
- Changes in skin pigmentation
- Folliculitis
- Secondary infections
- Delayed healing
Stop using the product and seek medical advice if you develop a significant allergic reaction, severe irritation or worsening of the skin condition.
Important Safety Information
Use METRACIN-PLUS only according to the directions of a qualified healthcare professional.
- This cream is intended for external topical use unless the approved product information states otherwise.
- Avoid contact with the eyes, mouth and other mucous membranes.
- Do not apply the cream to large areas of skin unless specifically advised.
- Avoid covering treated areas with tight or occlusive dressings unless instructed by a healthcare professional.
- Clobetasol Propionate is a very potent topical corticosteroid. Avoid prolonged or unnecessary use because corticosteroids can cause skin thinning and other local or systemic effects.
- Do not use the cream for an undiagnosed rash simply because it is itchy or red.
- Corticosteroids can sometimes mask or worsen fungal and bacterial infections, so continued treatment should follow professional assessment.
- Avoid routine use on the face, groin, underarms or skin folds unless specifically prescribed.
- Tell your doctor if you have a recurrent fungal infection, bacterial infection, open wound or other significant skin condition.
- Do not use the cream longer than recommended.
- Avoid applying other topical medicines to the same area unless your healthcare professional recommends them.
- Stop treatment and seek medical advice if the skin becomes significantly more irritated or the infection appears to spread.
- Children may be more susceptible to corticosteroid-related adverse effects, so use in children should follow medical advice.
- Inform your healthcare professional if you are pregnant, planning pregnancy or breastfeeding before using the product.
- Keep the product out of reach of children.
For additional information about topical corticosteroids and appropriate skin treatment, refer to the NHS guidance on topical corticosteroids.
Dosage & Administration
Apply METRACIN-PLUS exactly as prescribed by your healthcare professional.
The appropriate frequency and duration depend on the type of skin condition, affected area, severity of inflammation and clinical response. Therefore, a fixed treatment duration should not be assumed from the 15 GM pack size.
For general topical application:
- Clean and gently dry the affected area.
- Apply a thin layer of cream to the affected skin as directed.
- Gently spread the cream without vigorous rubbing.
- Wash your hands after application unless the treated area is the hands.
- Avoid contact with the eyes and mucous membranes.
- Do not apply more frequently or for longer than prescribed.
Do not use a larger quantity to obtain faster results. If symptoms do not improve, become worse or repeatedly return, consult a healthcare professional rather than continuing the cream on your own.
Storage
- Store METRACIN-PLUS in a cool and dry place.
- Protect the tube from excessive heat and direct sunlight.
- Keep the tube tightly closed when not in use.
- Keep the product in its original packaging.
- Protect from excessive moisture.
- Do not freeze unless the manufacturer’s instructions specifically permit it.
- Keep out of reach of children.
- Do not use after the expiry date printed on the packaging.
