Clozisen-Plus

Description

CLOZISEN-PLUS contains Beclomethasone Dipropionate 0.025%, Neomycin Sulphate 0.5% and Clotrimazole 1.0% in cream form. This combination brings together a topical corticosteroid, antibiotic and antifungal agent. It may be prescribed for selected skin conditions where fungal or bacterial involvement occurs together with inflammation, itching and redness.

CLOZISEN-PLUS is intended for external topical use and should be used according to the advice of a healthcare professional. Because topical corticosteroids can cause unwanted effects when used incorrectly or for prolonged periods, the cream should not be used routinely for undiagnosed skin rashes.

For related dermatology formulations and pharmaceutical products, explore the Medhexa Pharma product range for additional products and business enquiries.

Therapeutic Segment

Dermatology | Antifungal Therapy | Topical Antibiotics | Corticosteroids | Skin Infection Management

Uses of CLOZISEN-PLUS

CLOZISEN-PLUS may be prescribed for selected inflammatory skin conditions where a healthcare professional identifies a need for combined antifungal, antibacterial and anti-inflammatory treatment.

Depending on the diagnosis, it may help manage:

• Fungal skin infections accompanied by significant inflammation
• Selected superficial skin infections with bacterial involvement
• Itching, redness and inflammatory discomfort associated with susceptible skin conditions
• Skin conditions where fungal or bacterial infection occurs alongside inflammation
• Localized dermatological conditions requiring short-term combination treatment

The exact indication depends on the type of infection, severity, affected body area and clinical assessment.

CLOZISEN-PLUS should not be used automatically for every itchy or red skin rash. Many skin conditions can look similar, while the wrong treatment may delay appropriate diagnosis.

Key Benefits of CLOZISEN-PLUS

• Antifungal support: Clotrimazole helps control susceptible fungal organisms on the skin.
• Bacterial control: Neomycin provides antibacterial activity against susceptible bacteria.
• Inflammation relief: Beclomethasone Dipropionate helps reduce inflammatory skin responses.
• Helps reduce itching and redness: The corticosteroid component can relieve inflammatory symptoms associated with appropriate skin conditions.
• Three-component formulation: Combines antifungal, antibacterial and corticosteroid activity in one topical formulation.
• Convenient topical application: Supplied as a cream for external skin use.
• 15 gm pack: Convenient pack size for topical treatment as directed.

How CLOZISEN-PLUS Works

Each ingredient contributes a different therapeutic action.

Beclomethasone Dipropionate is a topical corticosteroid. It reduces inflammatory activity in the skin and can help relieve symptoms such as redness, swelling and itching.

Clotrimazole is an antifungal medicine. It interferes with the formation of fungal cell membranes, helping control susceptible fungi responsible for superficial fungal skin infections.

Neomycin Sulphate is an aminoglycoside antibiotic that acts against susceptible bacteria by interfering with bacterial protein synthesis.

Together, these ingredients provide complementary antifungal, antibacterial and anti-inflammatory activity. However, the combination should be used only when all components are clinically appropriate.

Common Side Effects of CLOZISEN-PLUS

Some people may experience local skin reactions after applying the cream. Possible effects include:

• Mild burning or stinging
• Irritation
• Redness
• Dryness
• Itching
• Skin discomfort
• Contact dermatitis or allergic reaction

Topical corticosteroids can cause additional problems when used for prolonged periods or over large areas. These may include:

• Skin thinning
• Stretch marks
• Changes in skin pigmentation
• Visible small blood vessels
• Increased susceptibility to local infection
• Delayed wound healing

Neomycin can also cause allergic contact dermatitis in some individuals.

Stop using the cream and seek medical advice if you develop significant irritation, worsening redness, swelling, blistering or other signs of an allergic reaction.

Important Safety Information

Use CLOZISEN-PLUS only according to the directions of a qualified healthcare professional.

• For external use only. Do not swallow the cream.
• Avoid contact with the eyes, mouth and other mucous membranes.
• Do not apply the cream to broken skin, open wounds or severely damaged skin unless specifically advised by a healthcare professional.
• Do not use the cream for prolonged periods without medical supervision.
• Topical corticosteroids can worsen or mask certain infections if used inappropriately.
• Do not use CLOZISEN-PLUS for an undiagnosed skin rash simply because it is itchy or red.
• Avoid covering the treated area with airtight dressings unless your healthcare professional specifically recommends this.
• Avoid applying the cream to large areas of the body unless directed by a healthcare professional.
• Use particular caution on the face, groin and skin folds because corticosteroid-related side effects may occur more readily in these areas.
• Do not use near the eyes unless specifically prescribed for that area.
• Children may be more susceptible to corticosteroid-related adverse effects, so pediatric use should follow professional advice.
• Neomycin can cause sensitization or allergic skin reactions in some people.
• Tell your healthcare professional if symptoms become worse, spread to other areas or fail to improve.
• Inform your doctor about any other topical or oral medicines you are using.
• Pregnant or breastfeeding women should seek medical advice before using the cream.
• Keep the product out of reach of children.

Topical corticosteroid safety depends on the potency, duration, application area and amount used. The NHS guidance on topical corticosteroids provides additional information about appropriate use and precautions.

For additional information about clotrimazole, refer to the NHS guidance on clotrimazole.

Dosage & Administration

Apply CLOZISEN-PLUS exactly as directed by your doctor or pharmacist.

Clean and dry the affected area before application unless otherwise instructed. Apply a thin layer of cream to the affected skin and gently spread it over the area.

The frequency and duration of treatment depend on the diagnosis, severity of the condition and response to treatment. Do not apply larger amounts or use the cream more frequently than recommended.

Avoid prolonged self-treatment. If the skin condition does not improve, becomes worse or spreads during treatment, consult a healthcare professional rather than continuing the cream without assessment.

Wash your hands before and after application unless the treated area itself is the hands.

Avoid contact with the eyes and mucous membranes. If accidental contact with the eyes occurs, rinse thoroughly with clean water and seek medical advice if irritation persists.

Do not use an occlusive dressing over the treated area unless specifically instructed by your healthcare professional.

Storage

• Store CLOZISEN-PLUS in a cool, dry place.
• Protect the cream from excessive heat and direct sunlight.
• Keep the tube tightly closed when not in use.
• Keep the product in its original packaging.
• Do not freeze unless the manufacturer’s instructions specifically permit it.
• Do not use the cream after the expiry date printed on the pack.
• Keep out of the reach and sight of children.