Clozyne-MN

Description

CLOZYNE-MN combines Clobetasol 0.05% w/w, Neomycin 0.5% w/w and Miconazole 2% w/w in topical cream form. This combination brings together a potent corticosteroid, an antibacterial agent and an antifungal agent. It may be prescribed for selected inflammatory skin conditions where fungal or bacterial involvement is suspected or confirmed and where treatment with all three components is considered appropriate.

CLOZYNE-MN is intended for external dermatological use only and should be used under the direction of a healthcare professional. The cream is available in a 15 GM pack.

For related dermatology and topical pharmaceutical formulations, explore the Medhexa Pharma product range for additional products and business enquiries.

Therapeutic Segment

Dermatology | Antifungal Therapy | Topical Antibiotics | Corticosteroids | Skin Infection Management

Uses of CLOZYNE-MN

CLOZYNE-MN may be prescribed for selected skin conditions involving inflammation, itching, redness and suspected or confirmed fungal or bacterial involvement, when a healthcare professional considers the combination appropriate.

Depending on the diagnosis, it may be considered for:

• Selected inflammatory skin conditions with fungal involvement
• Certain superficial fungal skin infections accompanied by significant inflammation
• Skin conditions where secondary bacterial involvement requires topical antibacterial treatment
• Selected corticosteroid-responsive dermatoses with associated fungal or bacterial concerns

The exact indication depends on the patient’s diagnosis, affected body area and clinical assessment. CLOZYNE-MN should not be used as a general-purpose cream for every rash, itching or skin infection.

Because clobetasol is a very potent corticosteroid, an appropriate diagnosis is particularly important before using this combination.

Key Benefits of CLOZYNE-MN

• Reduces inflammation and redness: Clobetasol helps suppress inflammatory activity in corticosteroid-responsive skin conditions.
• Helps fight fungal infections: Miconazole provides antifungal activity against susceptible fungi and yeasts.
• Provides antibacterial protection: Neomycin acts against susceptible bacteria that may contribute to certain skin infections.
• Soothes irritated skin: By reducing inflammation and associated irritation, the formulation may help improve skin discomfort.
• Three-component formulation: Combines corticosteroid, antifungal and antibacterial activities in one topical preparation.
• Convenient topical application: Cream formulation allows direct application to affected skin as prescribed.
• 15 GM pack: Supplied in a practical cream pack for dermatological use.

How CLOZYNE-MN Works

Each active ingredient contributes a different therapeutic action.

Clobetasol 0.05% w/w is a very potent topical corticosteroid. It acts on corticosteroid receptors in skin cells and suppresses inflammatory processes. This can help reduce redness, swelling, itching and irritation.

Miconazole 2% w/w is an antifungal medicine. It interferes with the production of ergosterol, an important component of fungal cell membranes. This damages susceptible fungal cells and helps control fungal growth.

Neomycin 0.5% w/w is an aminoglycoside antibiotic that acts against susceptible bacteria by interfering with bacterial protein synthesis.

Together, these ingredients can address inflammation plus selected fungal and bacterial involvement when all three treatment actions are clinically justified.

Common Side Effects of CLOZYNE-MN

Some people may experience local skin reactions after application. Possible effects include:

• Burning or stinging
• Itching
• Redness
• Dryness
• Skin irritation
• Peeling
• Folliculitis
• Changes in skin pigmentation

With prolonged or inappropriate use of potent topical corticosteroids, additional effects such as skin thinning, stretch marks and visible small blood vessels may occur.

Neomycin can also cause contact sensitization or allergic skin reactions in some individuals.

Seek medical advice if irritation becomes severe, the skin condition worsens or signs of an allergic reaction develop.

Important Safety Information

Use CLOZYNE-MN only as directed by a healthcare professional.

• CLOZYNE-MN is for external use only.
• Avoid contact with the eyes, mouth and other mucous membranes.
• Do not use it as a general treatment for an undiagnosed rash.
• Clobetasol is a very potent corticosteroid, so prolonged or unnecessary use can increase the risk of local and systemic corticosteroid-related adverse effects.
• Avoid applying the cream to large areas of the body unless specifically prescribed.
• Do not use under airtight or occlusive dressings unless your healthcare professional specifically instructs you to do so.
• Avoid routine application to the face, groin or underarms unless specifically prescribed.
• Corticosteroids can mask or worsen certain infections. If the skin condition becomes worse or spreads, seek medical reassessment.
• Do not continue treatment for longer than prescribed.
• Neomycin may cause allergic contact dermatitis in susceptible individuals. Stop use and seek medical advice if a new or worsening rash develops.
• Tell your healthcare professional if you have previously experienced an allergy to corticosteroids, neomycin, miconazole or other topical medicines.
• Inform your doctor about any other creams, ointments or medicines being applied to the same area.
• Children may be more susceptible to adverse effects from potent topical corticosteroids, so use in children should follow specific medical advice.
• Discuss use during pregnancy or breastfeeding with your healthcare professional before applying the product.
• Do not use the cream on broken skin, open wounds or severely damaged areas unless specifically advised.
• Keep out of reach of children.

For additional information about topical corticosteroids, refer to the NHS guidance on topical corticosteroids.

Dosage & Administration

Apply CLOZYNE-MN exactly as prescribed by your healthcare professional.

Before application, gently clean and dry the affected area unless otherwise instructed. Apply a thin layer to the affected skin and gently spread it over the area.

The frequency and duration of treatment depend on the diagnosis, severity of inflammation, location of the affected skin and response to treatment. Because CLOZYNE-MN contains clobetasol 0.05%, treatment should generally remain short term and medically supervised.

Do not apply larger quantities or use the cream more frequently than recommended. Avoid unnecessary application to unaffected skin.

If you miss an application, apply it when remembered unless it is nearly time for the next application. Do not apply an excessive amount to compensate for a missed application.

If the condition does not improve, becomes worse or develops new symptoms, consult your healthcare professional rather than continuing treatment on your own.

Storage

• Store CLOZYNE-MN in a cool, dry place.
• Protect the cream from excessive heat and direct sunlight.
• Keep the tube tightly closed when not in use.
• Store in the original packaging.
• Do not freeze the cream.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.