Description
SITLIPX-M500 contains Sitagliptin Phosphate I.P. 50 mg and Metformin HCl I.P. 500 mg in tablet form. This combination brings together two oral antidiabetic medicines with complementary actions. Sitagliptin helps increase glucose-dependent insulin release, while Metformin improves the body’s response to insulin and reduces glucose production by the liver. Together, they help improve blood glucose control in adults with type 2 diabetes mellitus when prescribed alongside appropriate diet and exercise.
For related diabetic and cardiovascular formulations, explore the Medhexa Pharma product range for pharmaceutical products and business enquiries.
Therapeutic Segment
Anti-Diabetic Therapy | Type 2 Diabetes Management | DPP-4 Inhibitors | Biguanides | Blood Glucose Control
Uses of SITLIPX-M500
SITLIPX-M500 may be prescribed as part of a treatment plan for:
- Type 2 diabetes mellitus
- Inadequate blood glucose control with diet and exercise alone
- Patients requiring combination therapy with Sitagliptin and Metformin
- Improving glycaemic control when treatment with either medicine alone does not provide adequate control
- Supporting long-term blood glucose management as part of an individualized diabetes-care plan
The combination is intended for type 2 diabetes and is not used to treat type 1 diabetes or diabetic ketoacidosis.
Key Benefits of SITLIPX-M500
- Dual-action formulation: Combines Sitagliptin and Metformin through complementary mechanisms.
- Supports blood glucose control: Helps improve glycaemic control in adults with type 2 diabetes.
- Sitagliptin 50 mg: Provides DPP-4 inhibitor activity that supports glucose-dependent insulin release.
- Metformin 500 mg: Helps reduce hepatic glucose production and improve insulin sensitivity.
- Combination convenience: Provides two established antidiabetic medicines in one tablet.
- Supports individualized diabetes therapy: May be prescribed when combination treatment is clinically appropriate.
How SITLIPX-M500 Works
Sitagliptin is a DPP-4 inhibitor. It increases the activity of incretin hormones, which helps the pancreas release insulin in response to elevated blood glucose. It also reduces glucagon secretion when blood glucose is elevated. These actions help lower blood glucose levels.
Metformin belongs to the biguanide class. It primarily reduces glucose production by the liver and also improves insulin sensitivity, helping the body use glucose more effectively.
Therefore, SITLIPX-M500 combines two complementary approaches to blood glucose management.
Common Side Effects of SITLIPX-M500
Some people may experience gastrointestinal effects, particularly when starting Metformin. Possible side effects include:
- Nausea
- Vomiting
- Diarrhoea
- Abdominal discomfort or stomach pain
- Loss of appetite
- Headache
- Indigestion
- Changes in taste
- Low blood sugar, particularly when used with other medicines that can cause hypoglycaemia
Metformin-related gastrointestinal effects often become less troublesome as the body adjusts to treatment.
Important Safety Information
Use SITLIPX-M500 only according to the advice of a qualified healthcare professional.
- Kidney function should be assessed before starting treatment and monitored as appropriate because Metformin and Sitagliptin require consideration of renal function.
- Metformin can rarely cause lactic acidosis, a serious condition. Seek urgent medical attention for unusual weakness, breathing difficulty, persistent sleepiness, severe stomach discomfort or other concerning symptoms.
- SITLIPX-M500 should not be used in patients with severe renal impairment. Current U.S. prescribing information specifies that sitagliptin/metformin combinations should not be used when eGFR is below 30 mL/min/1.73 m².
- Tell your doctor if you have kidney disease, liver disease, heart failure or a history of metabolic acidosis.
- Inform your healthcare professional before iodinated contrast imaging because Metformin may need to be temporarily discontinued depending on kidney function and the procedure.
- Sitagliptin can rarely cause pancreatitis. Seek medical attention for persistent severe abdominal pain that may extend to the back.
- Tell your doctor if you have previously experienced pancreatitis.
- Monitor for symptoms of low blood sugar, particularly if SITLIPX-M500 is used together with insulin or medicines such as sulfonylureas.
- Long-term Metformin treatment can reduce Vitamin B12 levels in some patients. Healthcare professionals may monitor B12 when clinically appropriate.
- Tell your doctor about all prescription medicines, vitamins, supplements and herbal products you use.
- Avoid excessive alcohol consumption because alcohol can increase the risk of Metformin-related complications and can also affect blood glucose control.
- Discuss pregnancy or breastfeeding with your healthcare professional before using the medicine.
- Continue appropriate diet, physical activity and blood glucose monitoring as advised by your diabetes-care team.
For additional information about Sitagliptin, refer to the NHS guidance on Sitagliptin.
Dosage & Administration
Take SITLIPX-M500 exactly as prescribed by your healthcare professional.
The appropriate regimen depends on the patient’s current diabetes treatment, blood glucose control, kidney function and tolerability. Current prescribing information for the 50 mg/500 mg sitagliptin-metformin combination specifies administration twice daily with meals in the referenced immediate-release formulation, while the exact regimen for an individual patient should follow the approved product information and prescription.
Taking the medicine with meals can help reduce gastrointestinal effects associated with Metformin.
Do not change the dose, stop treatment or take additional tablets without medical advice. If a dose is missed, follow the instructions provided by your healthcare professional rather than taking a double dose.
Storage
- Store in a cool, dry place.
- Protect the tablets from excessive heat and moisture.
- Keep the tablets in their original packaging until use.
- Keep out of the sight and reach of children.
- Do not use after the expiry date printed on the pack.
