Description
MECOHEX-NP contains Pregabalin I.P. 75 mg, Nortriptyline I.P. 10 mg and Methylcobalamin I.P. 1500 mcg, a combination used for the management of neuropathic or nerve-related pain when prescribed by a healthcare professional. Pregabalin helps reduce abnormal nerve signalling, while Nortriptyline can modify pain signals in the nervous system. Methylcobalamin is a form of vitamin B12 that supports normal nerve function.
For related tablet formulations and therapeutic segments, Medhexa Pharma Tablets can be referred to for additional product information.
Therapeutic Segment
Neuropathic Pain | Pain Management | Neurocare
Uses of MECOHEX-NP
MECOHEX-NP may be prescribed for the management of certain nerve-related pain conditions, including:
- Diabetic peripheral neuropathic pain
- Burning or shooting nerve pain
- Tingling or abnormal nerve sensations
- Numbness associated with nerve irritation
- Certain persistent neuropathic pain conditions
- Nerve-related pain where nutritional support with vitamin B12 is also considered appropriate
Pregabalin has established uses for certain neuropathic pain conditions, while nortriptyline can also be used for nerve pain. The exact cause of pain and the suitability of this combination should be assessed by a healthcare professional.
Key Benefits of Pregabalin, Nortriptyline and Methylcobalamin
- Contains Pregabalin I.P. 75 mg
- Contains Nortriptyline I.P. 10 mg
- Contains Methylcobalamin I.P. 1500 mcg
- Combines medicines that act on different aspects of nerve-related pain
- Supports the management of neuropathic pain symptoms
- Methylcobalamin provides vitamin B12 support for normal nerve function
- Available in convenient tablet form
- Supplied in 10 × 10 ALU-ALU packaging
How MECOHEX-NP Works
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system. This reduces the release of certain neurotransmitters involved in abnormal nerve signalling and can help reduce neuropathic pain.
Nortriptyline belongs to the tricyclic antidepressant group. When used for nerve pain, it changes the way nerves process and transmit pain signals. Therefore, it can help reduce persistent nerve-related discomfort.
Methylcobalamin is a form of vitamin B12 involved in normal neurological function and red blood cell formation. Consequently, it provides nutritional support alongside the medicines used for nerve pain.
Common Side Effects of MECOHEX-NP
Some people may experience:
- Dizziness
- Sleepiness or drowsiness
- Tiredness
- Dry mouth
- Constipation
- Blurred vision
- Headache
- Difficulty concentrating
- Swelling of the hands or feet
- Weight gain
Pregabalin commonly causes dizziness and sleepiness, while nortriptyline can cause dry mouth, constipation, dizziness and drowsiness.
However, side effects vary between individuals. Contact your healthcare professional if side effects become severe, persistent or interfere with daily activities.
Important Safety Information
Use MECOHEX-NP only according to the advice of a doctor or pharmacist.
Pregabalin and Nortriptyline can cause drowsiness, dizziness or blurred vision. Therefore, do not drive, operate machinery or perform activities requiring full alertness until you know how the medicine affects you. Alcohol can also increase drowsiness.
Tell your doctor if you have kidney disease, heart problems, liver disease, glaucoma, urinary retention, epilepsy or other significant medical conditions. Pregabalin requires dose adjustment in adults with reduced kidney function, while nortriptyline may not be suitable for some people with heart or other medical conditions.
Also, inform your healthcare professional about all medicines you take. In particular, medicines that cause drowsiness, certain antidepressants, opioids and other medicines affecting the nervous system may increase the risk of adverse effects.
Do not stop MECOHEX-NP suddenly without medical advice. Pregabalin should be tapered gradually rather than stopped abruptly, and nortriptyline may also require gradual dose reduction to reduce withdrawal symptoms.
Seek urgent medical attention if you develop facial or throat swelling, difficulty breathing, fainting, a fast or irregular heartbeat, severe confusion or other serious symptoms.
For additional information about Pregabalin, refer to the NHS guidance on Pregabalin.
Dosage & Administration
The appropriate dose and treatment duration depend on the patient’s condition, response to treatment, kidney function, age and other medicines being taken. Therefore, take MECOHEX-NP only in the dose prescribed by your healthcare professional.
Swallow the tablet with water. It may be taken with or without food unless your doctor provides different instructions.
Because Pregabalin requires dose adjustment in patients with reduced renal function, do not change the dose yourself.
If you miss a dose, follow your doctor’s or pharmacist’s instructions. Do not take a double dose to compensate for a missed dose.
Storage
- Store MECOHEX-NP in a cool and dry place.
- Protect the tablets from excessive heat and moisture.
- Keep the tablets in their original packaging until use.
- Keep out of reach of children.
- Follow the storage instructions printed on the product packaging.
