Glipden-M2 1000

Description

GLIPDEN-M2 1000 contains Metformin Hydrochloride (as prolonged release) 1000 mg and Glimepiride 2 mg in tablet form. This combination brings together two oral antidiabetic medicines with complementary actions. Metformin helps reduce glucose production by the liver and improve insulin sensitivity, while Glimepiride stimulates insulin release from the pancreas. Together, they may help improve blood glucose control in adults with type 2 diabetes mellitus when prescribed alongside appropriate diet and exercise.

For related diabetic and cardiovascular formulations, explore the Medhexa Pharma Cardries Biotic range for additional pharmaceutical products and business enquiries.

Therapeutic Segment

Anti-Diabetic Therapy | Type 2 Diabetes Management | Biguanides | Sulfonylureas | Prolonged-Release Metformin | Blood Glucose Control

Uses of GLIPDEN-M2 1000

GLIPDEN-M2 1000 may be prescribed as part of an individualized treatment plan for:

• Type 2 diabetes mellitus
• Inadequate blood glucose control with diet and exercise alone
• Patients requiring combination therapy with Metformin and Glimepiride
• Patients who need additional glycaemic control despite treatment with a single oral antidiabetic medicine
• Long-term blood glucose management when combination therapy is considered appropriate

The formulation is intended for type 2 diabetes. It should not be used to treat type 1 diabetes or diabetic ketoacidosis.

Key Benefits of GLIPDEN-M2 1000

• Dual-action formulation: Combines Metformin and Glimepiride through complementary mechanisms.
• Blood glucose support: Helps improve glycaemic control in adults with type 2 diabetes.
• Metformin 1000 mg PR: Provides prolonged-release Metformin to support glucose management and improve insulin sensitivity.
• Glimepiride 2 mg: Stimulates pancreatic insulin release to help lower blood glucose.
• Prolonged-release formulation: The Metformin component releases gradually according to the formulation design.
• Convenient combination therapy: Provides two established antidiabetic medicines in one tablet.

How GLIPDEN-M2 1000 Works

Metformin Hydrochloride belongs to the biguanide class. It primarily reduces glucose production by the liver and also improves the body’s sensitivity to insulin. As a result, the body can use circulating glucose more effectively.

The prolonged-release formulation releases Metformin over an extended period according to its formulation characteristics, supporting convenient administration.

Glimepiride belongs to the sulfonylurea class. It stimulates pancreatic beta cells to release insulin. This additional insulin helps move glucose from the bloodstream into tissues and lowers blood glucose levels.

Therefore, GLIPDEN-M2 1000 combines reduced hepatic glucose production and improved insulin sensitivity with increased insulin secretion.

Common Side Effects of GLIPDEN-M2 1000

Some people may experience side effects, particularly during the initial stages of treatment. Possible effects include:

• Nausea
• Diarrhoea
• Abdominal discomfort
• Stomach pain
• Loss of appetite
• Indigestion
• Changes in taste
• Headache
• Dizziness
• Hypoglycaemia

Metformin-related gastrointestinal effects often become less troublesome as the body adjusts to treatment. Glimepiride, however, can cause low blood glucose, particularly when meals are skipped or calorie intake is inadequate.

Seek medical attention for severe or persistent hypoglycaemia, confusion, loss of consciousness, breathing difficulty or other serious symptoms.

Important Safety Information

Use GLIPDEN-M2 1000 only according to the advice of a qualified healthcare professional.

• Monitor blood glucose regularly as recommended by your diabetes-care team.
• Hypoglycaemia: Glimepiride can cause low blood glucose. The risk may increase if meals are skipped, calorie intake is inadequate, alcohol is consumed or other glucose-lowering medicines are used.
• Take the medicine according to the prescribed meal schedule and avoid routinely skipping meals.
• Kidney function: Metformin requires appropriate assessment of renal function before and during treatment.
• Metformin can rarely cause lactic acidosis, a serious condition. Seek urgent medical attention for severe weakness, unusual sleepiness, breathing difficulty, persistent vomiting or severe abdominal discomfort.
• GLIPDEN-M2 1000 should not be used when Metformin is contraindicated, including severe renal impairment.
• Tell your doctor if you have kidney disease, liver disease, heart failure, severe infection or a history of metabolic acidosis.
• Inform your healthcare professional before undergoing imaging procedures involving iodinated contrast because Metformin may require temporary interruption depending on kidney function and the procedure.
• Long-term Metformin treatment can reduce Vitamin B12 levels in some patients. Healthcare professionals may monitor B12 levels when clinically appropriate.
• Tell your doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or a history of significant anaemia before using Glimepiride.
• Avoid excessive alcohol consumption because it can affect blood glucose control and may increase the risk of Metformin-related complications.
• Tell your healthcare professional about all prescription medicines, over-the-counter medicines, vitamins and supplements you take.
• Discuss pregnancy or breastfeeding with your healthcare professional before using the medicine.
• Do not stop or change diabetes treatment without medical advice.
• Keep the medicine out of the reach of children.

For additional information about Metformin, refer to the NHS guidance on Metformin.

Dosage & Administration

Take GLIPDEN-M2 1000 exactly as prescribed by your healthcare professional.

The appropriate dose and administration schedule depend on the patient’s blood glucose control, previous antidiabetic treatment, kidney function, tolerability and the specific prolonged-release formulation.

Because GLIPDEN-M2 1000 contains prolonged-release Metformin, swallow the tablet whole with water. Do not crush, chew or split the tablet unless the approved product information specifically allows it.

Take the medicine with or immediately after a meal according to your healthcare professional’s instructions. Taking Metformin with food can help reduce gastrointestinal discomfort, while regular meals can also reduce the risk of Glimepiride-associated hypoglycaemia.

Do not increase the dose or take additional tablets if blood glucose remains elevated. Your healthcare professional may adjust treatment based on blood glucose results and tolerability.

If you miss a dose, follow your healthcare professional’s instructions. Do not take a double dose to compensate for a missed tablet.

Storage

• Store GLIPDEN-M2 1000 in a cool, dry place.
• Protect the tablets from excessive heat and moisture.
• Keep the tablets away from direct sunlight.
• Keep the tablets in their original BLISTER packaging until use.
• Keep out of the sight and reach of children.
• Do not use the product after the expiry date printed on the packaging.