METZANE25

Description

METZANE25 contains Metoprolol Succinate Extended Release 25 mg in tablet form. Metoprolol succinate belongs to the beta-blocker class and primarily reduces the effects of adrenaline and related hormones on the heart. As a result, it can slow the heart rate, reduce cardiac workload and help manage blood pressure and selected cardiovascular conditions when prescribed by a healthcare professional.

For related cardiovascular and antihypertensive formulations, explore the Medhexa Pharma product range for pharmaceutical products and business enquiries.

Therapeutic Segment

Cardiovascular Care | Antihypertensive Therapy | Beta Blockers | Heart Failure Management | Blood Pressure Management

Uses of METZANE25

Healthcare professionals may prescribe METZANE25 as part of an individualized treatment plan for:

• High blood pressure (hypertension)
• Angina pectoris
• Certain heart rhythm disorders
• Long-term cardiovascular management
• Selected patients with stable heart failure, as part of appropriate medical therapy
• Patients who require extended-release beta-blocker treatment

The exact indication depends on the patient’s cardiovascular condition, heart rate, blood pressure and overall treatment plan. Metoprolol succinate extended-release formulations have established uses in hypertension, angina and selected patients with heart failure.

Key Benefits of METZANE25

• Beta-1 Selective Action: Primarily reduces beta-1 adrenergic stimulation of the heart at appropriate therapeutic doses.
• Heart Rate Control: Helps slow an elevated heart rate when clinically appropriate.
• Blood Pressure Management: Helps lower blood pressure as part of antihypertensive therapy.
• Reduced Cardiac Workload: Reduces heart rate and cardiac workload, which can decrease the heart’s oxygen demand.
• Extended-Release Formulation: Provides prolonged metoprolol exposure from an extended-release dosage form.
• 25 mg Strength: Provides Metoprolol Succinate ER 25 mg in each tablet.

How METZANE25 Works

Metoprolol succinate selectively blocks beta-1 adrenergic receptors in the heart at appropriate therapeutic doses.

Normally, adrenaline and related hormones stimulate these receptors and increase heart rate and the force of cardiac contraction. By reducing this stimulation, metoprolol slows the heart rate and decreases cardiac workload.

Metoprolol also reduces renin release from the kidneys. This action can contribute to its blood-pressure-lowering effect.

The extended-release formulation releases metoprolol gradually, helping maintain its effect throughout the dosing interval.

Common Side Effects of METZANE25

Some people may experience side effects during treatment. Possible effects include:

• Tiredness or fatigue
• Dizziness
• Slow heart rate
• Low blood pressure
• Shortness of breath
• Cold hands or feet
• Diarrhoea
• Nausea
• Headache
• Sleep disturbance

These effects may become more noticeable when treatment begins or when the dose changes.

Important Safety Information

Use METZANE25 only according to the advice of a qualified healthcare professional.

Heart Rate and Blood Pressure

Metoprolol can slow the heart rate and lower blood pressure. Healthcare professionals may monitor pulse and blood pressure, particularly when starting treatment or adjusting the dose.

Do Not Stop Suddenly

Do not abruptly stop METZANE25, especially if you use it for coronary artery disease. Sudden withdrawal can worsen angina and may increase the risk of serious cardiovascular events. A healthcare professional should guide any dose reduction or discontinuation.

Heart Failure

Patients with heart failure may experience worsening symptoms or fluid retention when treatment begins or when the dose increases. Healthcare professionals generally start with a suitable dose and increase it gradually according to tolerance.

Asthma and Breathing Conditions

Although metoprolol primarily targets beta-1 receptors, beta-blockers can affect the airways at higher concentrations. Tell your doctor if you have asthma, chronic obstructive pulmonary disease or another breathing disorder.

Diabetes and Low Blood Sugar

Metoprolol can mask some warning signs of low blood sugar, particularly a rapid heartbeat. Patients with diabetes should monitor blood glucose carefully and discuss any changes in diabetes treatment with their healthcare professional.

Circulation Problems

Tell your doctor if you have severe peripheral circulation problems, Raynaud’s phenomenon or another condition affecting blood flow to the limbs.

Drug Interactions

Tell your healthcare professional about all prescription medicines, over-the-counter medicines and supplements you use. Important interactions can occur with medicines that slow the heart rate, lower blood pressure or affect metoprolol metabolism, including certain calcium channel blockers and CYP2D6 inhibitors.

For detailed prescribing information, refer to the DailyMed prescribing information for Metoprolol Succinate Extended Release.

Dosage & Administration

Take METZANE25 exactly as prescribed by your healthcare professional.

The appropriate dose depends on the condition being treated, heart rate, blood pressure and individual response. Therefore, follow the prescribed regimen rather than changing the dose yourself.

Metoprolol succinate extended-release tablets are generally taken once daily and should be taken consistently, preferably with or immediately after a meal.

Swallow the extended-release tablet whole unless the specific product instructions permit another method. Do not crush or chew an extended-release tablet.

For heart failure, healthcare professionals generally begin treatment at a low dose and gradually increase it according to tolerance. For hypertension and angina, the prescribed dose depends on the patient’s clinical response and treatment requirements.

If you miss a dose, follow your healthcare professional’s instructions. Do not take an extra dose to compensate for a missed tablet.

Storage

• Store METZANE25 in a cool, dry place.
• Protect the tablets from excessive heat and moisture.
• Keep the tablets in their original ALU-ALU packaging until use.
• Protect from direct sunlight.
• Keep out of the sight and reach of children.
• Do not use the product after the expiry date printed on the pack.