METZANE-50

Description

METZANE-50 contains Metoprolol Succinate Extended Release 50 mg in tablet form. Metoprolol succinate is a selective beta-1 adrenergic receptor blocker that reduces the effects of certain stress hormones on the heart. As a result, it slows the heart rate, reduces the heart’s workload and can help manage blood pressure and selected cardiovascular conditions when prescribed by a healthcare professional.

For related cardiovascular and antihypertensive formulations, explore the Medhexa Pharma product range for pharmaceutical products and business enquiries.

Therapeutic Segment

Cardiovascular Care | Antihypertensive Therapy | Beta Blockers | Heart Failure Management | Blood Pressure Management

Uses of METZANE-50

Healthcare professionals may prescribe METZANE-50 as part of an individualized treatment plan for:

• High blood pressure (hypertension)
• Angina pectoris
• Certain heart rhythm disorders
• Long-term cardiovascular management
• Selected patients with stable heart failure, as part of guideline-directed therapy
• Patients who require extended-release beta-blocker treatment

The exact indication depends on the patient’s cardiovascular condition, heart rate, blood pressure and overall treatment plan. Metoprolol succinate extended release has established indications for hypertension, angina and certain heart-failure patients.

Key Benefits of METZANE-50

• Beta-1 Selective Action: Primarily reduces beta-1 adrenergic stimulation of the heart.
• Heart Rate Control: Helps slow an elevated heart rate when clinically appropriate.
• Blood Pressure Management: Helps reduce blood pressure as part of antihypertensive therapy.
• Reduced Cardiac Workload: Decreases the heart’s demand for oxygen by reducing heart rate and contractile activity.
• Extended-Release Formulation: Provides prolonged metoprolol exposure from a once-daily extended-release dosage form.
• 50 mg Strength: Provides Metoprolol Succinate ER 50 mg in each tablet.

How METZANE-50 Works

Metoprolol succinate belongs to the beta-blocker class and selectively blocks beta-1 adrenergic receptors at appropriate therapeutic doses.

Normally, adrenaline and related hormones stimulate beta-1 receptors in the heart, increasing heart rate and the force of contraction. By reducing this stimulation, metoprolol slows the heart rate and decreases cardiac workload.

Metoprolol also reduces renin release from the kidneys. This additional action can contribute to its blood-pressure-lowering effect.

The extended-release formulation releases metoprolol gradually, helping maintain drug exposure over the dosing interval.

Common Side Effects of METZANE-50

Some people may experience side effects during treatment. Possible effects include:

• Tiredness or fatigue
• Dizziness
• Slow heart rate
• Low blood pressure
• Shortness of breath
• Cold hands or feet
• Diarrhoea
• Nausea
• Headache
• Sleep disturbance

These effects may be more noticeable when treatment begins or when the dose changes.

Important Safety Information

Use METZANE-50 only according to the advice of a qualified healthcare professional.

Heart Rate and Blood Pressure

Metoprolol can slow the heart rate and lower blood pressure. Healthcare professionals may monitor pulse and blood pressure, particularly when starting treatment or adjusting the dose.

Do Not Stop Suddenly

Do not abruptly stop METZANE-50, particularly when using it for coronary artery disease. Sudden withdrawal can worsen angina and, in some patients, increase the risk of serious cardiovascular events. A healthcare professional should guide any dose reduction or discontinuation.

Heart Failure

Patients with heart failure may experience worsening symptoms or fluid retention when treatment begins or when the dose increases. Healthcare professionals generally increase the dose gradually and monitor the patient’s response.

Asthma and Breathing Conditions

Although metoprolol primarily targets beta-1 receptors, beta-blockers can affect the airways at higher concentrations. Tell your doctor if you have asthma, chronic obstructive pulmonary disease or another breathing disorder.

Diabetes and Low Blood Sugar

Metoprolol can mask some warning signs of low blood sugar, particularly a rapid heartbeat. Patients with diabetes should monitor glucose carefully and discuss any changes in diabetic treatment with their healthcare professional.

Circulation Problems

Tell your doctor if you have severe peripheral circulation problems, Raynaud’s phenomenon or other conditions that affect blood flow to the limbs.

Drug Interactions

Tell your healthcare professional about all medicines and supplements you use. Important interactions can occur with medicines that slow the heart rate, lower blood pressure or affect metoprolol metabolism, including certain calcium channel blockers and CYP2D6 inhibitors.

For detailed prescribing information, refer to the DailyMed prescribing information for Metoprolol Succinate Extended Release.

Dosage & Administration

Take METZANE-50 exactly as prescribed by your healthcare professional.

Because the appropriate dose depends on the condition being treated, heart rate, blood pressure and individual response, follow the prescribed regimen rather than adjusting the dose yourself.

Metoprolol succinate extended-release tablets are generally taken once daily and should be taken consistently, preferably with or immediately after a meal. Swallow the extended-release tablet whole unless the specific product instructions permit another method. Do not crush or chew an extended-release tablet.

For hypertension, the labeled adult starting dose can vary depending on the formulation and clinical situation. For heart failure, healthcare professionals use a lower starting dose and increase it gradually according to tolerance.

If you miss a dose, follow your healthcare professional’s instructions. Do not take an extra dose to compensate for a missed tablet.

Storage

• Store METZANE-50 in a cool, dry place.
• Protect the tablets from excessive heat and moisture.
• Keep the tablets in their original ALU-ALU packaging until use.
• Protect from direct sunlight.
• Keep out of the sight and reach of children.
• Do not use the product after the expiry date printed on the pack.