DALAZIN-5

Description

DALAZIN-5 contains Dapagliflozin 5 mg in tablet form. Dapagliflozin belongs to the sodium-glucose cotransporter 2 (SGLT2) inhibitor class. It works through the kidneys by reducing glucose and sodium reabsorption, which increases their excretion in urine. As a result, dapagliflozin can help improve blood glucose control in appropriate patients with type 2 diabetes when prescribed alongside suitable diet, exercise and medical care.

For related diabetic and cardiovascular formulations, explore the Medhexa Pharma product range for pharmaceutical products and business enquiries.

Therapeutic Segment

Anti-Diabetic Therapy | Type 2 Diabetes Management | SGLT2 Inhibitors | Blood Glucose Control | Cardiovascular Care

Uses of DALAZIN-5

Healthcare professionals may prescribe DALAZIN-5 as part of an individualized treatment plan for:

• Type 2 diabetes mellitus
• Improving glycaemic control alongside appropriate diet and exercise
• Patients who require an SGLT2 inhibitor as part of diabetes management
• Blood glucose management when lifestyle measures alone do not provide adequate control
• Patients who may benefit from dapagliflozin therapy according to their clinical condition

Dapagliflozin also has established cardiovascular and kidney-related indications in appropriate patients. The exact indication depends on the patient’s diagnosis, kidney function, cardiovascular status and applicable prescribing information.

Dapagliflozin is not recommended for improving glycaemic control in patients with type 1 diabetes because of the risk of diabetic ketoacidosis.

Key Benefits of DALAZIN-5

• SGLT2 Inhibitor: Provides Dapagliflozin 5 mg for appropriate SGLT2 inhibitor therapy.
• Blood Glucose Support: Helps lower blood glucose by increasing urinary glucose excretion.
• Renal Mechanism: Acts on SGLT2 proteins in the kidneys to reduce glucose and sodium reabsorption.
• Diuretic Effect: Promotes urinary glucose and sodium excretion, which also increases urine output.
• 5 mg Strength: Provides Dapagliflozin 5 mg in each tablet.
• Convenient Oral Form: Supplied as an oral tablet for once-daily administration when prescribed.

How DALAZIN-5 Works

Dapagliflozin selectively inhibits the SGLT2 protein located in the proximal renal tubules.

Normally, the kidneys reabsorb a large amount of filtered glucose and sodium. By blocking SGLT2, dapagliflozin reduces this reabsorption. Consequently, the kidneys remove more glucose and sodium from the body through urine.

This action helps lower blood glucose levels and produces a mild diuretic effect. The changes in glucose, sodium and fluid handling also contribute to dapagliflozin’s broader cardiovascular and kidney-related effects in appropriate patients.

Common Side Effects of DALAZIN-5

Some people may experience side effects during dapagliflozin treatment. Possible effects include:

• Increased urination
• Increased thirst
• Genital fungal infections
• Urinary tract infections
• Dizziness
• Dehydration or reduced fluid volume
• Changes in blood lipid levels

Because dapagliflozin increases glucose in the urine, genital and urinary infections may occur more readily in some patients.

Important Safety Information

Use DALAZIN-5 only according to the advice of a qualified healthcare professional.

Dehydration and Low Blood Pressure

Dapagliflozin increases urinary glucose and sodium excretion. Therefore, it can increase urine output and reduce fluid volume. Patients who are elderly, taking diuretics or already dehydrated may have a higher risk of low blood pressure or volume depletion.

Kidney Function

Healthcare professionals should assess kidney function before and during treatment when clinically appropriate. Kidney function also affects the medicine’s suitability and effectiveness for different indications.

Diabetic Ketoacidosis

Dapagliflozin can cause diabetic ketoacidosis, including cases where blood glucose does not appear extremely high. Seek urgent medical attention if symptoms such as nausea, vomiting, abdominal pain, unusual tiredness or difficulty breathing occur.

The risk may increase during prolonged fasting, acute illness, major surgery or significant reduction in insulin. Your healthcare professional may advise temporarily stopping dapagliflozin before certain procedures.

Genital and Urinary Infections

Dapagliflozin increases glucose excretion through urine, which can increase the risk of genital fungal infections and urinary tract infections. Contact a healthcare professional if you develop burning during urination, unusual genital discharge, severe irritation or other concerning symptoms.

Serious Genital Infection

Rarely, SGLT2 inhibitors have been associated with necrotizing fasciitis of the perineum (Fournier’s gangrene). Seek immediate medical attention for severe pain, tenderness, redness or swelling around the genital or perineal area, especially when accompanied by fever or feeling unwell.

Low Blood Sugar

Dapagliflozin alone generally has a low risk of hypoglycaemia. However, the risk can increase when it is used together with insulin or insulin-releasing medicines such as sulfonylureas. Healthcare professionals may adjust accompanying medicines when appropriate.

Pregnancy and Breastfeeding

Dapagliflozin is generally avoided during the later stages of pregnancy because of potential effects on fetal kidney development. Discuss pregnancy, planned pregnancy or breastfeeding with your healthcare professional before using the medicine.

For detailed prescribing information, refer to the DailyMed prescribing information for Dapagliflozin.

Dosage & Administration

Take DALAZIN-5 exactly as prescribed by your healthcare professional.

For adults with type 2 diabetes, current prescribing information lists 5 mg once daily as an initial dose for glycaemic control. Healthcare professionals may increase the dose to 10 mg once daily when additional glycaemic control is required and when clinically appropriate.

For heart failure or chronic kidney disease indications, the prescribed dose may differ from the regimen used specifically for glycaemic control. Therefore, follow the indication-specific prescription provided by your healthcare professional.

DALAZIN-5 may be taken with or without food. Take the tablet at approximately the same time each day unless your healthcare professional provides different instructions.

Do not increase the dose, stop treatment or take additional tablets without medical advice.

Storage

• Store DALAZIN-5 in a cool, dry place.
• Protect the tablets from excessive heat and moisture.
• Keep the tablets in their original ALU-ALU packaging until use.
• Protect from direct sunlight.
• Keep out of the sight and reach of children.
• Do not use the product after the expiry date printed on the pack.